I've just finished rewriting my MegaHAL/Irssi script to be a lot cleaner and a lot easier to configure. You can get it from the MegaHAL/Irssi page.

New features include:

• Configurable using standard Irssi /set commands instead of hacking the script
• Supports changing nick without hacking the script
• Generally requires less hacking of the script ...

So, erm, yes. Enjoy!